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Studying the secret life of organometallic complexes inside cells

Friday, January 26, 2018 - 12:00
Place: 
Donostia International Physics Center
Who: 
Dr. Carlos Sanchez-Cano, University of Warwick, UK
Source Name: 
DIPC

Organometallic piano stool complexes are
tuneable systems capable of acting as therapeutic agents1,2,3 and/or
intracellular catalysts3,4,5. However, although their chemical
behaviour and antiproliferative properties are well studied, the cellular
mechanisms followed by these systems to produce the biological responses
observed remain mostly unknown until now.

The recent
development of new nanoprobes beamlines such as ID16A and ID16B (ESRF), or I08
and I14 (DIAMOND), allows focusing synchrotron radiation below 100x100 nm2.
Performing nano-X-ray fluorescence (nano-XRF), nano-X-ray absorption
spectroscopy (nano-XAS) and similar techniques on those beamlines enables
direct detection of metals with unprecedented sensitivity, the spatial
resolution required to analyse biological samples at subcellular level,2
and the ability to provide chemical information about the studied metal.6

These
techniques are particularly suitable to explore the interaction of metal
complexes with cells. State-of-the-art nanofocused synchrotron radiation is a
powerful tool that allows to use a combination of different imaging and
spectroscopic techniques to study their subcellular localisation and
intracellular chemical behaviour with exceptional detail.2,6 This
can help to obtain a better understanding of the intracellular targets and
mechanisms followed by metal complexes ultimately leading to their biological
effects in cells and organisms.

1.  Angew. Chem. Intl. Ed., 2017, 56, 1017

2.  Chem.
Eur. J.,
2017, 23, 2512

3.  Dalton
Trans,
2016, 45, 8367

4.  Chem.
Eur. J.,
2015, 21, 8043

5.  Nat.
Chem, Manuscript accepted

6.  Manuscript
in preparation

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